The pupils get smaller and do not respond to light. Some drugs, most commonly opioids such as heroin, cause pinpoint pupils. This symptom tends to wear off, along with the other effects of the drug. Pupil dilation is also associated with heroin and opioid withdrawal. However, this symptom can result from ingesting alcohol, mescaline, cocaine, ecstasy, LSD, psilocybin (magic mushrooms), MDMA (Molly/Ecstasy), amphetamines, cannabis, inhalants, narcotics, hallucinogens, bath salts, ketamine, and SSRI antidepressants. Stimulants and psychotropic drugs most commonly cause pupil dilation. This chemical reaction leads to mydriasis, the muscle relaxation that expands the eye’s pupil and lets in more light. Some drugs trigger the body’s fight-or-flight adrenaline response by interacting with serotonin and adrenergic receptors in the brain. Distance, medications, color, drug use, and underlying health factors like sexual attraction and arousal can also play a role.ĭilated pupils, an enlargement of the black portion of the center of the eye, are one common symptom of drug use. However, light is not the only factor that can affect pupil dilation. The dilation of the pupil is an involuntary nervous system response to light that protects your eyes from too much light and aids your vision when in poorly lit areas. When the light is too bright, your pupils will constrict to minimize the amount getting into your eyes and dilate (widen) in dim light. The pupils naturally dilate depending on your exposure to light. The round opening in the center of the iris (the colored tissue that makes the “eye color” at the front of the eye).
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